Study Finds Two-Dose Vaccines Induce Lower Antibodies Against Omicron

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Two-dose COVID-19 vaccine regimens do not induce enough neutralizing antibodies against the Omicron coronavirus variant, British scientists found, indicating that increased infections in those previously infected or vaccinated may be likely.

Researchers from the University of Oxford published results on Monday from a study yet to be peer-reviewed, where they analyzed blood samples from participants who were given doses from AstraZeneca-Oxford (AZN.L) or Pfizer-BioNTech (PFE.N), (22UAy.DE) in a large study looking into the mixing of vaccines.

The results come a day after British Prime Minister Boris Johnson warned that two shots will not be enough to contain Omicron, following findings from the UK health agency last week that boosters significantly restore protection against the variant.

The Oxford study said that there was no evidence yet that the lower level of infection-fighting antibodies against Omicron could lead to a higher risk of severe disease, hospitalization, or death in those who have got two doses of approved vaccines.

“These data are important but are only one part of the picture. They only look at neutralizing antibodies after the second dose but do not tell us about cellular immunity, and this will also be tested,” said Matthew Snape, Oxford professor and co-author of the paper.

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